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First, poor predictive validity of animal models is a major issue: preclinical models often fail to recapitulate the complexity of human disease, including heterogeneity of immune activation, comorbidities, and temporal dynamics (125)

Piekarz RL, Frye R, Prince HM et al (2011) Phase 2 trial of romidepsin in patients with peripheral T-cell lymphoma

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Traditionally, enzyme-based biosensors have dominated the field of electrochemical biosensing because of their rapid response and high selectivity